Edinburgh RONIN-Meeting: Workshop WP2-WP3 – Modelling health-disease transition in NAFL to NASH in preclinical liver models

Program

The event was held on St Leonards Hall.

Thursday 08/02/24

Session I: Introduction

09:30 – Registration | Refreshments
10:00 – Welcome to Edinburgh. Lenny Nelson
10:30 – Introduction & Overview of Halt-RONIN Consortium. Javier Cubero (Project Coordinator)
 
Session II: Clinical Perspectives in NAFLD-NASH
 
10:30 – What’s the problem?. Jonathan Fallowfield | Tim Kendall
11:00 Spanish Clinical Hub | Overview – Connect Online. Marina Villanueva Paz/ Ismael Álvarez/ Maribel Lucena/ Javier Crespo
11:20 – ☕ Coffee break 
 
Session III: HepaRG-based NAFLD-NASH Modelling
 
11:40 – LiverAce- Liver acinus-on-a-chip. Lenny Nelson
12:10 – HepaRG Bioenergetics in NAFDL. Shaden Melhem
12:30 – Biophysical profiling of the NAFDL-NASH transmition. Pierre Bagnaninchi
12:50 – Q&A
13:00 – 🍴 Lunch
 
Session IV: 3D HepaRG-based multicellular systems
 
14:00 – Experimental plan 3D HepaRG-based systems | POR. Michel Kranendonk | Francisco Esteves
14:30 – HCYP2E1. Bernard Fromenty | Karima Begriche | Maela Duclos
15:00 – Perspective: Cholangiocyte Pathobiology. Anabel Martinez Lyons
15:20 – Q&A
15:30 – ☕ Coffee break
15:20 – iPSC-derived 3D lever systems for NAFLD-NASH. Pau Sancho | Joana P G Miranda & Co
16:30 – Q&A | Discussion
 
19:30 🍴 Dinner
 
 
Friday 09/02/24
 
Session I: WP3 – In vivo | WP4 – Data Integration

10:00 – Humanized Zebrafish update. Gulcin Cakan | Ozlen Konu
11:00 – ☕ Coffee break
 
Session II: Modelling | Transcriptomics | Bioinformatics | Database integration
 
11:20 – DUAL Mouse Model. Javier Cubero/ Héctor Leal
11:50 – Mechanistic pathways: e.g. ER Stress/ Mitochondria – ROS axis Exosomes. Héctor Leal
12:05 – Mice with humanized liver to model human MASLD. Prof. Fernández-Checa
12:30 – Q&A | Discussion
12:40 – 3D Models | Extracellular Vesicles Unified SOP for WP2-3. Felix Royo/ Juan Manuel Falcón
13:10 – 🍴 Lunch
 
Session III:
 
14:00 – SteatoSITE – Clinical validation. Jonathan Fallowfield | Tim Kendall
14:30 – Q&A | Discussion
14:40 – WP4 – Data Integration – Anaxomics. Judith Farres
15:40 – ☕ Coffee break
 
Session IV: KPI’s | Milestones | Deliverables | Discussion
 
16:00 – Who? What? Where? When?… Javier Cubero | Michel Kranendonk | Lenny Nelson | Joana P G Miranda
17:00 – Discussion + Round table + Brainstorming