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INSERM (Institut national de la santé et de la recherche médicale) is a French public scientific institute dedicated to biomedical research and human health. The Institute of Nutrition, Metabolisms and Cancer (NuMeCan, Inserm U-1317) hosted by the University of Rennes is run by ca. 130 staff members from different entities including INSERM, University of Rennes and INRAE (Institut national de recherche pour l’agriculture, l’alimentation et l’environnement). NuMeCan is composed of 3 teams including the EXPRES team that
investigates the role of exogenous (including xenobiotics) and endogenous stresses in the occurrence of different hepatic diseases including metabolic dysfunction-associated steatotic liver disease (MASLD), liver cancer and drug-induced liver injury (DILI). EXPRES team mainly participates in WP2 devoted to in vitro investigations aimed at investigating the role of hepatic cytochrome P450 2E1 (CYP2E1) on MASLD progression in response to some nutrients (fatty acids, fructose) or drugs (acetaminophen). To assess the impact of CYP2E1 induction on MASLD progression, a 3-D liver organoid model (the so-called HML organoids) which has been recently developed in our laboratory will be used. This model combines HepaRG cells (which under controlled conditions differentiate into hepatocytes and cholangiocytes), M1 macrophages derived from buffy coat-isolated monocytes and hepatic stellate LX-2 cels.

The team