Good morning,
We warmly welcome you to the International Seminar Series on Liver Toxicity and Steatotic Liver Disease. Remember that in order to improve our understanding of the topic and to promote collaboration in our research efforts, we will be organising a series of seminars every month.
Next week, we have a new session, on 21st January (Wednesday) from 16:30h to 17:30h (CET). Your participation is vital to enrich the discussions, and we look forward to hearing your ideas.
SAVE THE DATE
Transcriptomics-driven insights into steatotic liver disease and liver toxicity: from data integration to actionable molecular signatures
DATE: 21st January at 16:30h (CET)
GUEST: Thomas Darde
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Steatotic liver disease and liver toxicity involve complex and heterogeneous molecular programs that are challenging to capture with single endpoints. In this talk, I will present how transcriptomics and robust bioinformatics workflows can help identify reproducible pathway-level signals and molecular signatures across cohorts and experimental models. I will highlight practical considerations for study design, QC, integration of public RNA-seq datasets, and validation strategies to avoid common analytical pitfalls. Finally, I will discuss how these approaches can support translational interpretation and biomarker prioritization in the context of MASLD and liver toxicity research. Brief biographical note Thomas Darde is the founder of SciLicium (France), a bioinformatics company specializing in transcriptomics and toxicogenomics for translational research and applied biomedical projects. His work focuses on RNA-seq analytics, data integration, biomarker discovery, and reproducible pipelines, supporting both academic consortia and industry programs. He is involved in the HALT-RONIN Horizon Europe project, contributing to data analysis and the development of reusable analytical resources.